• 99% Purity Nootropics Pharmaceutical Material Galantamine Hydrobromide CAS 1953-04-4

99% Purity Nootropics Pharmaceutical Material Galantamine Hydrobromide CAS 1953-04-4

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99% Purity Nootropic Pharmaceutical Material Galantamine Hydrobromide CAS:1953-04-4

 

Quick Details:

 

Product Name: Galantamine Hydrobromide

CAS No.: 1953-04-4

MF: C17H22BrNO3

MW: 368.27

EINECS: 217-780-5

Product Categories: Intermediates & Fine Chemicals, API

Melting point: 256 °C

Storage temp.: -20°C

Color: White to Off-White Powder

 

Product NameGalantamine Hydrobromide
SynonymsNIVALIN;NIVALIN, HBR;4A,5,9,10,11,12-HEXAHYDRO-3-METHOXY-11-METHYL-6H-BENZOFURO[3A,3,2-EF][2]BENZAZEPIN-6-OL HYDROBROMIDE;GALANTAMINE HBR;GALANTAMINE HYDROBROMIDE;GALANTHAMIDE HYDROBROMIDE;GALANTHAMINE HBR;GALANTHAMINE HYDROBROMIDE
CAS1953-04-4
MFC17H22BrNO3
MW368.27
EINECS217-780-5

 

Description:

 

Galantamine hydrobromide is the hydrobromide salt of galantamine and is a cholinesterase inhibitor can be extracted from Amaryllidaceae Lycoris plant. The III-phase clinical trials in the United Kingdom in 1998 have showed that this drug had dual mechanism of action of both inhibiting acetylcholinesterase and regulating nicotinic receptors. Therefore, galantamine can improve the cognitive abilities of Alzheimer's patients and has been already applied as the drug of the treatment of mild to severe Alzheimer's disease (AD) drugs and has entered into market in EC countries. "Chinese Pharmacopoeia" has included the both the raw material and injection of galantamine hydrobromide. It is clinically mainly used for the treatment of poliomyelitis (polio) sequelae, muscular dystrophy and myasthenia gravis. It can be used to substitute neostigmine methyl-sulfate for antagonism of tubocurarine but with weak performance with the usage amount being ten times as high as the usage amount of neostigmine methyl-sulfate.

 

Functions:

 

This product is anticholinesterase drugs, a weaker anticholinesterase role, through the blood-brain barrier, so the role of the central nervous system is relatively strong. The obstruction of nerve and muscle conduction recovery, improve the various peripheral neuromuscular disorders paralysis.

 

The treatment of a wide range of less toxic, more tolerable patients. Clinical mainly for the treatment of poliomyelitis (poliomyelitis) sequelae, muscle atrophy and myasthenia gravis. Can also be used for children with cerebral palsy, traumatic sensory dyskinesia, polyneuritis and spinal nerve root inflammation.

 

Application:

 

This product is anticholinesterase drugs, a weaker anticholinesterase role, through the blood-brain barrier, so the role of the central nervous system is relatively strong. The obstruction of nerve and muscle conduction recovery, improve the various peripheral neuromuscular disorders paralysis.

 

The treatment of a wide range of less toxic, more tolerable patients. Clinical mainly for the treatment of poliomyelitis (poliomyelitis) sequelae, muscle atrophy and myasthenia gravis. Can also be used for children with cerebral palsy, traumatic sensory dyskinesia, polyneuritis and spinal nerve root inflammation.

 

Side Effects:

 

Galantamine's side effect profile was very similar to that of other cholinesterase inhibitors, with gastrointestinal symptoms being the most notable and most commonly observed. One study reports higher proportions of patients treated with galantamine experiencing nausea and vomiting as opposed to the placebo group. Another study using a dose-escalation treatment has found that incidences of nausea would decrease to baseline levels soon after each increase in administered dosage. In practice, some other cholinesterase inhibitors might be better tolerated; however, a careful and gradual titration over more than three months may lead to equivalent long-term tolerability.

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